Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis.

Inflammatory Mediators in Gastroesophageal Reflux Disease

30 31 Gastroesophageal reflux disease (GERD) is one of the most common problems in clinical 32 practice today. It is widely believed that functional and structural abnormalities of the 33 gastroesophageal junction as well as an abnormal exposure to gastroduodenal contents are the 34 main contributors to its pathogenesis. Novel findings of the inflammatory process in GERD 35 suggest a far more c...

Inflammation and Oxidative Stress in Gastroesophageal Reflux Disease

The etiology of esophageal mucosal injury is complex, since it may involve the reflux of gastric acid, bile acid, and pancreatic juice, external factors such as drugs and alcohol, or functional factors such as esophagogastric motility. The mechanism of esophageal mucosal injury has gradually been understood at the molecular biological level. It is particularly important that pro-inflammatory fa...

Author's response to reviews Title:The Prevalence of Gastro-Esophageal Reflux Disease and Esophageal Dysmotility in Chinese Patients with Idiopathic Pulmonary Fibrosis Authors:

Gender is a risk factor in patients with gastroesophageal reflux disease

Background: Prevalence of gastroesophageal reflux disease (GERD) has increased in the last decades, and it is now one of the most common chronic and recurrent diseases. The present study aimed at determining the frequency of gender (sex) and age in Iranian patients with GERD symptoms.    Methods: In this study, 803 patients aged 11 to 84 years, with erosive and nonerosive gastroesoph...

What is the real impairment on esophageal motility in patients with gastroesophageal reflux disease?

CONTEXT Impairment of esophageal motility is a common finding in patients with gastroesophageal reflux disease (GERD) as reduced lower esophageal sphincter (LES) basal pressure. A very low LES pressure might facilitate the occurrence of more gastroesophageal reflux whereas abnormal esophageal peristalsis may contribute to impaired esophageal clearance after reflux. OBJECTIVE Evaluate the esop...